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Takahiro Yamauchi Selected Research

9-arabinofuranosylguanine

9/2014A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine.
7/2014Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line.
4/2013Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcomes the cytarabine resistance in HL-60 leukemia cell line.
2/2010A new high-performance liquid chromatography method determines low production of 9-beta-D-arabinofuranosylguanine triphosphate, an active metabolite of nelarabine, in adult T-cell leukemia cells.

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Takahiro Yamauchi Research Topics

Disease

31Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
04/2022 - 11/2003
24Neoplasms (Cancer)
04/2022 - 02/2002
24Leukemia
02/2019 - 06/2002
9Lymphoma (Lymphomas)
01/2021 - 03/2007
8Pancreatic Neoplasms (Pancreatic Cancer)
07/2016 - 06/2010
7Hematologic Neoplasms (Hematological Malignancy)
10/2022 - 11/2006
6Neutropenia
10/2022 - 03/2002
6Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2021 - 11/2012
5Febrile Neutropenia
10/2022 - 12/2013
5Pneumonia (Pneumonitis)
08/2021 - 05/2009
5Disease Progression
05/2021 - 09/2012
5Multiple Myeloma
01/2021 - 01/2014
5Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
08/2020 - 02/2010
5Acute Promyelocytic Leukemia
11/2018 - 02/2003
5Hyperuricemia
01/2015 - 04/2008
4Thrombocytopenia (Thrombopenia)
01/2022 - 12/2013
4Infections
02/2021 - 03/2002
4Nausea
04/2019 - 12/2013
4Disseminated Intravascular Coagulation
11/2018 - 01/2011
4Tumor Lysis Syndrome
12/2016 - 10/2014
4Colonic Neoplasms (Colon Cancer)
07/2011 - 03/2010
4Carcinogenesis
07/2011 - 05/2007
3Myelodysplastic Syndromes (Myelodysplastic Syndrome)
08/2022 - 07/2007
3Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
07/2021 - 12/2018
3Anemia
01/2020 - 12/2013
3Vomiting
04/2019 - 11/2017
3BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
02/2014 - 06/2008
2Liver Diseases (Liver Disease)
10/2022 - 10/2017
2Fever (Fevers)
03/2021 - 01/2017
2Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
03/2021 - 12/2017
2Bacteremia
02/2021 - 04/2013
2Sepsis (Septicemia)
02/2021 - 06/2002
2Inflammation (Inflammations)
01/2020 - 01/2018
2Hematoma
10/2018 - 10/2017
2Neoplasm Metastasis (Metastasis)
10/2017 - 03/2002
2Hemorrhage
10/2017 - 01/2011
2Pancytopenia
01/2017 - 10/2012
2Myeloid Leukemia (Leukemia, Myelocytic)
10/2014 - 04/2014
2Hematologic Diseases (Blood Diseases)
04/2013 - 10/2012

Drug/Important Bio-Agent (IBA)

13Cytarabine (Cytosar-U)FDA LinkGeneric
08/2021 - 02/2003
9Pharmaceutical PreparationsIBA
01/2021 - 11/2006
8Uric Acid (Urate)IBA
05/2015 - 04/2008
6venetoclaxIBA
01/2022 - 10/2020
6DNA (Deoxyribonucleic Acid)IBA
07/2019 - 11/2002
6ErbB Receptors (EGF Receptor)IBA
12/2011 - 06/2010
5Prednisolone (Predate)FDA LinkGeneric
06/2021 - 06/2002
5Anti-Bacterial Agents (Antibiotics)IBA
03/2021 - 12/2013
4Melphalan (Alkeran)FDA LinkGeneric
01/2021 - 07/2007
4Bortezomib (Velcade)FDA Link
01/2021 - 12/2016
4Clofarabine (Clolar)FDA Link
10/2020 - 09/2011
4Phosphotransferases (Kinase)IBA
11/2015 - 06/2008
4Carmustine (FIVB)FDA Link
08/2015 - 11/2002
49-arabinofuranosylguanineIBA
09/2014 - 02/2010
4Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2014 - 03/2005
4GemcitabineFDA Link
12/2011 - 11/2006
4Epidermal Growth Factor (EGF)IBA
07/2011 - 03/2010
4Proteins (Proteins, Gene)FDA Link
06/2010 - 04/2008
3Azacitidine (5 Azacytidine)FDA Link
08/2022 - 05/2021
3Vincristine (Oncovin)FDA LinkGeneric
01/2021 - 02/2015
3nelarabine (506U78)FDA Link
10/2019 - 02/2010
3forodesineIBA
01/2019 - 09/2014
3Dacarbazine (DIC)FDA LinkGeneric
11/2018 - 01/2011
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
09/2017 - 02/2002
3Rituximab (Mabthera)FDA Link
09/2017 - 01/2014
3FebuxostatFDA Link
01/2015 - 10/2014
3p38 Mitogen-Activated Protein KinasesIBA
11/2011 - 06/2010
3triphosphoric acid (triphosphate)IBA
09/2011 - 11/2006
3Cyclin D1IBA
07/2011 - 03/2008
3rho-Associated KinasesIBA
07/2011 - 03/2010
2Gemtuzumab (Mylotarg)FDA Link
03/2021 - 10/2014
2Purine-Nucleoside PhosphorylaseIBA
01/2019 - 09/2014
2ThrombomodulinIBA
11/2018 - 01/2011
2SurvivinIBA
12/2017 - 09/2012
2R-CHOP protocolIBA
12/2017 - 11/2012
2Methotrexate (Mexate)FDA LinkGeneric
10/2017 - 02/2014
2Immunoglobulin G (IgG)IBA
01/2017 - 01/2017
2Dexamethasone (Maxidex)FDA LinkGeneric
01/2017 - 02/2014
2Platelet-Derived Growth FactorIBA
07/2016 - 04/2012
2Becaplermin (PDGF-BB)FDA Link
07/2016 - 04/2012
2Temozolomide (Temodar)FDA LinkGeneric
08/2015 - 07/2008
2purineIBA
12/2014 - 01/2014
2Xanthine OxidaseIBA
12/2014 - 10/2014
2Dasatinib (BMS 354825)FDA Link
02/2014 - 06/2011
2Alanine Transaminase (SGPT)IBA
12/2013 - 05/2007
2Messenger RNA (mRNA)IBA
08/2013 - 10/2012
22- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphateIBA
07/2013 - 10/2011
2Arabinofuranosylcytosine TriphosphateIBA
04/2013 - 06/2009
2Antineoplastic Agents (Antineoplastics)IBA
04/2013 - 12/2011
2Interleukin-2 Receptors (IL 2 Receptor)IBA
01/2013 - 11/2012
2Cyclosporine (Ciclosporin)FDA LinkGeneric
09/2012 - 06/2002
2Aurora Kinase BIBA
09/2012 - 10/2011
2Heat-Shock Proteins (Heat-Shock Protein)IBA
12/2011 - 06/2010
2fludarabineIBA
10/2011 - 02/2007
22-fluoro-araATPIBA
09/2011 - 02/2007

Therapy/Procedure

29Therapeutics
10/2022 - 03/2002
28Drug Therapy (Chemotherapy)
10/2022 - 03/2002
3Hematopoietic Stem Cell Transplantation
10/2022 - 10/2013
3Induction Chemotherapy
05/2021 - 01/2011
3Remission Induction
01/2011 - 06/2002
2Radiotherapy
10/2017 - 05/2009